PittsburghV1, Main, Exploration, bibRecord, 003E33

Apolipoprotein E Allele and Hearing Thresholds in Older Adults

Identifieur interne : 003E33 ( Main/Exploration ); précédent : 003E32; suivant : 003E34

Apolipoprotein E Allele and Hearing Thresholds in Older Adults

Auteurs : David J. Mener [États-Unis] ; Joshua Betz [États-Unis] ; Kristine Yaffe [États-Unis] ; Tamara B. Harris ; Elizabeth P. Helzner ; Suzanne Satterfield ; Denise K. Houston [États-Unis] ; Elsa S. Strotmeyer [États-Unis] ; Sheila R. Pratt [États-Unis] ; Eleanor M. Simonsick [États-Unis] ; Frank R. Lin [États-Unis]

Source :

American journal of Alzheimer's disease and other dementias [ 1533-3175 ] ; 2014.

RBID : PMC:4258173

Descripteurs français

KwdFr :
- Allèles, Apolipoprotéine E4 (génétique), Femelle, Humains, Mâle, Perte d'audition (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Troubles de la cognition (génétique), Vieillissement, Études transversales.
MESH :
- génétique : Apolipoprotéine E4, Perte d'audition, Troubles de la cognition.
- Allèles, Femelle, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Vieillissement, Études transversales.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging, Alleles, Apolipoprotein E4 (genetics), Cognition Disorders (genetics), Cross-Sectional Studies, Female, Hearing Loss (genetics), Humans, Male.
MESH :
- chemical , genetics : Apolipoprotein E4.
- genetics : Cognition Disorders, Hearing Loss.
- Aged, Aged, 80 and over, Aging, Alleles, Cross-Sectional Studies, Female, Humans, Male.

Abstract

Background

Whether ApolipoproteinE (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown.

Methods

We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5 kHz–4kHz) in the better hearing ear.

Results

Compared to participants with no APOE-E4 alleles, participants with one allele had better thresholds at 4.0kHz (β= −2.72dB, p = 0.013) and 8.0 kHz (β= −3.05kHz, p = 0.006), and participants with two alleles had better hearing thresholds at 1.0kHz (β= −8.56dB, p=0.021).

Conclusion

Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258173

DOI: 10.1177/1533317514537549
PubMed: 24906966
PubMed Central: 4258173

Affiliations:

Le document en format XML

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</affiliation>
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<author><name sortKey="Helzner, Elizabeth P" sort="Helzner, Elizabeth P" uniqKey="Helzner E" first="Elizabeth P." last="Helzner">Elizabeth P. Helzner</name>
<affiliation><nlm:aff id="A7">Department of Epidemiology and Biostatistics, State University of New York Downstate Medical Center, University of Tennessee, Memphis</nlm:aff>
<wicri:noCountry code="subfield">Memphis</wicri:noCountry>
</affiliation>
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<author><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name>
<affiliation><nlm:aff id="A8">Department of Preventive Medicine, University of Tennessee, Memphis</nlm:aff>
<wicri:noCountry code="subfield">Memphis</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Wake Forest School of Medicine, Sticht Center on Aging, Winston Salem, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Wake Forest School of Medicine, Sticht Center on Aging, Winston Salem</wicri:cityArea>
</affiliation>
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<author><name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pratt, Sheila R" sort="Pratt, Sheila R" uniqKey="Pratt S" first="Sheila R." last="Pratt">Sheila R. Pratt</name>
<affiliation><nlm:aff id="A12">Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare Center</nlm:aff>
<wicri:noCountry code="subfield">VA Pittsburgh Healthcare Center</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A13">University of Pittsburgh, Department of Communication Science & Disorders</nlm:aff>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
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</placeName>
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<author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Lin, Frank R" sort="Lin, Frank R" uniqKey="Lin F" first="Frank R." last="Lin">Frank R. Lin</name>
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<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
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<affiliation wicri:level="3"><nlm:aff id="A3">Center on Aging and Health, Johns Hopkins Medical Institutions, University of California, San Francisco</nlm:aff>
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<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Center on Aging and Health, Johns Hopkins Medical Institutions, University of California</wicri:orgArea>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Alleles</term>
<term>Apolipoprotein E4 (genetics)</term>
<term>Cognition Disorders (genetics)</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Hearing Loss (genetics)</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term>
<term>Apolipoprotéine E4 (génétique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Perte d'audition (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Troubles de la cognition (génétique)</term>
<term>Vieillissement</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
<term>Hearing Loss</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term>
<term>Perte d'audition</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging</term>
<term>Alleles</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allèles</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Vieillissement</term>
<term>Études transversales</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Whether ApolipoproteinE (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5 kHz–4kHz) in the better hearing ear.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Compared to participants with no APOE-E4 alleles, participants with one allele had better thresholds at 4.0kHz (β= −2.72dB, p = 0.013) and 8.0 kHz (β= −3.05kHz, p = 0.006), and participants with two alleles had better hearing thresholds at 1.0kHz (β= −8.56dB, p=0.021).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
<li>San Francisco</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<name sortKey="Helzner, Elizabeth P" sort="Helzner, Elizabeth P" uniqKey="Helzner E" first="Elizabeth P." last="Helzner">Elizabeth P. Helzner</name>
<name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Mener, David J" sort="Mener, David J" uniqKey="Mener D" first="David J." last="Mener">David J. Mener</name>
</region>
<name sortKey="Betz, Joshua" sort="Betz, Joshua" uniqKey="Betz J" first="Joshua" last="Betz">Joshua Betz</name>
<name sortKey="Betz, Joshua" sort="Betz, Joshua" uniqKey="Betz J" first="Joshua" last="Betz">Joshua Betz</name>
<name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name>
<name sortKey="Lin, Frank R" sort="Lin, Frank R" uniqKey="Lin F" first="Frank R." last="Lin">Frank R. Lin</name>
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   |area=    PittsburghV1
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   |clé=     PMC:4258173
   |texte=   Apolipoprotein E Allele and Hearing Thresholds in Older Adults
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Serveur d'exploration sur Pittsburgh

Apolipoprotein E Allele and Hearing Thresholds in Older Adults

Apolipoprotein E Allele and Hearing Thresholds in Older Adults

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Pour mettre un lien sur cette page dans le réseau Wicri

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	Serveur d'exploration sur Pittsburgh
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